There is strong evidence that genetic as well as environmental factors affect the development of periodontitis, and some suggestion that aggressive and chronic forms of the disease share the same genetic predisposition.
genetic
This study addresses the hypothesis that there are both shared and unique genetic associations in these forms of periodontitis.
A sample of 51 patients with aggressive disease, 57 patients with chronic disease, and 100 healthy controls was recruited for this study. Ten functional polymorphisms in 7 candidate genes were genotyped.
The results show statistically significant (p <or= 0.05) differences between genotype frequencies in aggressive and controls ( IL-1B +3954 & IL-6 -174 ); chronic and controls ( IL-6 -174 & VDR -1056 ); chronic and aggressive periodontitis ( IL-1A -889); and periodontitis as a whole and controls ( VDR -1056, TLR-4 399 & IL-6 -174 ). These results suggest that there are in fact both shared and unique genetic associations in aggressive and chronic periodontitis.
J Dent Res. 2005 Dec;84:1149-53
Functional gene polymorphisms in aggressive and chronic periodontitis.
* Brett PM, * Zygogianni P, * Griffiths GS, * Tomaz M, * Parkar M, * D'Aiuto F, * Tonetti M.
environmental
HSV allows adhesion of bacteria
herpesvirus-infected periodontitis lesions tend to harbor elevated levels of classic periodontopathic bacteria, including Porphyromonas gingivalis, Dialister pneumosintes, Prevotella intermedia, Prevotella nigrescens, Campylobacter rectus, Treponema denticola and Actinobacillus (Aggregatibacter) actinomycetemcomitans.
Herpesviral-bacterial synergy in the pathogenesis of human periodontitis.2007
Periodontitis as a risk factor
Evaluation of the Incidence of Preterm Low Birth Weight in Patients Undergoing Periodontal Therapy., 2007
