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- Lipid composition of biological membranes. (A) Lipid composition of subcellular compartments expressed as mol% of the total cell lipid content. Insert: average lipid composition of a mammalian cell. (B) Distribution of lipids among subcellular compartments expressed as mol% of the total amount of a given lipid class in the whole cell. Data were renormalised by combining previously published data on subcellular lipid compositions [204206] with surface area of the corresponding subcompartment [207]. Graphical data were converted to numerical values and adjusted to the same average sum. These were then multiplied by the relative surface areas of the corresponding subcompartments (IA). For (B) each lipid class was set to 100%. ER, endoplasmic reticulum; Mit, mitochondria; PM, plasma membrane; ES + LS, Endosomes and Lysosomes; PC, phosphatidylcholine; PE, phosphatidylethanolamine; SM, sphingomyelin; PI, phosphatidylinositol; BMP, bis(monoacylglycero)phosphate; cl, cardiolipin (diphosphatidylglycerol)
Membrane lipid therapy: Modulation of the cell membrane composition and structure as a molecular base for drug discovery and new disease treatment., 2015
