Stress responses in flavivirus-infected cells: activation of unfolded protein response and autophagy, 2014
- Polyprotein Zika virus 3,423 W8QFH2_9FLAV
- Genome polyprotein Zika virus 257 W8NVK9_9FLAV
- E protein Zika virus 504 A0A060H177_9FLAV
DYRK1A
The DYRK1A Gene is a Cause of Syndromic Intellectual Disability With Severe Microcephaly and Epilepsy, 2012
Dual specificity tyrosine-phosphorylation-regulated kinase 1A is an enzyme that in humans is encoded by the DYRK1A gene. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region.These variants encode at least five different isoform
Required for innate immune defense against viruses. Acts downstream of DDX58/RIG-I and IFIH1/MDA5, which detect intracellular dsRNA produced during viral replication, to coordinate pathways leading to the activation of NF-kappa-B, IRF3 and IRF7, and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection, peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection, whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics, which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis
