Carnitine
Miscellaneous dietary supplements

Carnitine is a quaternary ammonium compound biosynthesized from the amino acids lysine and methionine.In living cells, it is required for the transport of fatty acids from the cytosol into the mitochondria during the breakdown of lipids (fats) for the generation of metabolic energy. It is widely available as a nutritional supplement.

Metabolism

Factors required for Carnitine synthesis

• trimethyl-lysine (on protein)
  • 3 x S-adenosyl-methionine
  • protein lysine
• Protein digestion in lysosomes
  • high protons production
• Mitochondrial hydroxylation (outer membrane)
  • Fe++, Ascorbate, 2- oxoglutarate
• Cytosol
  • NAD
• Cytosol, Peroxisomes
  • Fe++, Ascorbate, 2- oxoglutarate

more details......

Carnitine synthesis

Carnitine Bristol UK

the enzymes.....

Database	Link
BRENDA - The Comprehensive Enzyme Information System	"URL":
KEGG Pathways	"URL":
Human Metabolome Database	"URL":

the corresponding genes ......

Database	Link
Wikigenes	ACADM
GeneCards	"URL":
Your Favorite Gene Sigma	"URL":

Function

THE GENES

Database	Link
Wikigenes	ACADM
GeneCards	"URL":
Your Favorite Gene Sigma	"URL":

Carnitine dependent metabolic pathways

mi piace la carnitina perchè mia zia la mangiava a pranzo