Prothrombin
Coagulation

Author: Gianpiero Pescarmona
Date: 18/02/2010

Description

Prothrombin is the Thrombin precursor.

The conversion of prothrombin to the active enzyme thrombin is crucial for proper clot formation.

This conversion is handled by the membrane-bound prothrombinase complex, which contains a protease that sequentially cleaves the prothrombin precursor at Arg320 followed by Arg271. This defined chain of events is believed to occur through exosite-dependent binding of prothrombin to prothrombinase, arranging the substrate so to precisely present Arg320 in the protease active site.

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Prothrombinase-activity-458.gifgp18/02/2010
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