Author: Gabriele Ventura
γ-Aminobutyric acid (GABA) is the chief inhibitory neurotransmitter in the mammalian central nervous system. It plays a role in regulating neuronal excitability throughout the nervous system and in humans is also directly responsible for the regulation of muscle tone (relaxation).
Metabolic pathways of GABA.
Inhibition of mitochondrial oxidative phosphorylation induces hyper-expression of glutamic acid decarboxylase in pancreatic islet cells. 1999
GABA and Glycine figure
GABA and Glycine text
GABA in C Elegans
Differences in cardiovascular responses to peripherally administered GABA as influenced by basal conditions and type of anaesthesia, 1986
Various GABAA receptor agonists (homotaurine, muscimol, THIP, 5-aminovaleric acid) mimicked the 'excitatory' effect of GABA in reserpine pretreated animals anaesthetized with barbitone and prevented the effects of subsequent GABA administration. On the other hand (±)- baclofen, a selective GABAB receptor agonist, had a slight depressant effect and did not prevent the 'excitatory' cardiovascular effects of GABA.
Oral L-glutamine increases GABA levels in striatal tissue and extracellular fluid [The FASEB Journal • Research Communication]