Protein arginine methyltransferases (PRMT) catalyze methylation of nitrogen of specific arginine residues in proteins.
Type I and II PRMTs both catalyze monomethylation of the guanidinium (ω) nitrogen of specific arginine residues in proteins;
- Type I PRMTs modify proteins by the catalysis of asymmetric NG,NG-dimethylarginine
- Type II PRMTs catalyze the formation of symmetric NG,N′G-dimethylarginine.
- Type III enzymes catalyze only the monomethylation of arginine residues in proteins
Protein Arginine Methyltransferases: from Unicellular Eukaryotes to Humans 2007
Asimmetric dimethyl arginine