Proopiomelanocortin (POMC)
Pituitary Hormones

Author: Gianpiero Pescarmona
Date: 31/05/2010

Description

DEFINITION

Proopiomelanocortin is a polypeptide with 241 amino acid residues, precursor of some pituitary hormones.

The release of any of the fragments (eg ACTH) will increase also the release of the other peptides (alpha-MSH, beta-Endorphin etc)
Eg: Sun exposure increases MSH release but also endorphins (pleasure). Alternatively pleasant activity can induce tanning without sun.

THE GENE

DatabaseLink
HGNCACADM
Uniprot"URL":

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

  • Primary structure
  • Secondary structure
  • Tertiary structure
  • Quaternary structure

AA Percentage

Agouti related protein (AGRP)-expressing neurons are a key hypothalamic population that is activated during energy deficit and increases appetite and weight-gain.

Proopiomelanocortin (POMC)-expressing neurons, an intermingled population that suppresses appetite and body weight.

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis
post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

Effects of pro-opiomelanocortin (POMC) on food intake and body weight: mechanisms and therapeutic potential? 2007

lateral hypothalamus (LH)

LH food intake

Paraventricular Nucleus (PVN)

paraventricular nucleus and energy expenditure

** KEGG Pathways
** Human Metabolome Database
* Cell signaling and Ligand transport
* Structural proteins

REGULATION

DIAGNOSTIC USE

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