MN1
Transcription Factors

DEFINITION

MN1 is a gene found on human chromosome 22. Its official full name is meningioma (disrupted in balanced translocation) 1 because it is disrupted by a balanced translocation (4;22) in a meningioma.

Database	Link
Wikigenes	MN1
GeneCards	MN1
KEGG Pathways	MN1

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

• Primary structure
• Secondary structure
• Tertiary structure
  • PDB
• Quaternary structure

Protein Aminoacids Percentage

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis
post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization

• Nuclear

Cell signaling

MN1 is a transcription coregulator which enhances or represses RAR/RXR-mediated gene transcription through interaction with RAC3 and p300

• The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription 2003

MN1 also acts as a coactivator of the vitamin D receptor.

• The 1,25(OH)2D3-regulated transcription factor MN1 stimulates vitamin D receptor-mediated transcription and inhibits osteoblastic cell proliferation. 2005
  • Vitamin D reduces the expression of collagen and key profibrotic factors by inducing an antifibrotic phenotype in mesenchymal multipotent cells. 2008

Meningioma 1 gene is differentially expressed in CD34 positive cells from bone marrow of patients with myelodysplastic syndromes with the highest expression in refractory anemia with excess of blasts and secondary acute myeloid leukemia. 2008

MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression. 2008 Fulltext

REGULATION

DIAGNOSTIC USE

file	user	date
MN1.gif	gp	07/08/2010