Sphingomyelinase
Ceramide

Author: Gianpiero Pescarmona
Date: 03/02/2011

Description

DEFINITION

Sphingomyelin phosphodiesterase or simply Sphingomyelinase (SMase) is a hydrolase enzyme that breaks sphingomyelin (SM) down into phosphocholine and ceramide. The activation of SMase has been suggested as a major route for the production of ceramide in response to cellular stresses.

THE GENE

DatabaseLink
WikigenesSMPD1SMPD2SMPD3SMPD4
GeneCards"SMPD1":"SMPD2":"SMPD3":"SMPD4":
Your Favorite Gene Sigma"SMPD1":"SMPD2":"SMPD3":"SMPD4":

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

  • Primary structure
  • Secondary structure
  • Tertiary structure
  • Quaternary structure


Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Protein Aminoacids Percentage (Width 700 px)

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis

post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

  • Enzymes
DatabaseLink
BRENDA - The Comprehensive Enzyme Information SystemSMPDKEGG Pathways"URL":
Human Metabolome Database"URL":
  • Cell signaling and Ligand transport
  • Structural proteins

REGULATION

DIAGNOSTIC USE

Attachments
fileuserdate
SMPD1_4ch1.gifgp03/02/2011
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