Melanosomes
Acid Vesicles

Author: Gianpiero Pescarmona
Date: 12/07/2011

Description

Melanosome are tissue-specific lysosome-related organelles of pigment cells in which melanins are synthesized and stored.

Melanosome cargo

Powering membrane traffic in endocytosis and recycling, 2006

Electron microscopy analyses of MNT-1 human melanoma cells fixed by high-pressure freezing before cryosubstitution and embedding. The four stages of melanosome development are shown in the upper panels. Note the dense bilayered coat (arrowhead) and intralumenal vesicles (arrow) of stage I melanosomes, the proteinaceous fibrils (arrow) of stage II, and the melanin deposition (black) in stages III and IV. The main panel shows a typical field of MNT-1 cytoplasm near the nucleus, which contains all four stages of melanosomes. M, mitochondria; N, nucleus. Scale bar represents 0.5 m.

Melanosomes — dark organelles enlighten endosomal membrane transport, 2007

Melanosomes Are Specialized Members of the Lysosomal Lineage of Organelles, 1995

Subcellular fractionation of cultured normal human melanocytes: new insights into the relationship of melanosomes with lysosomes and peroxisomes 1993

The Epidermis and the Origin of Cutaneous Structures Epidermis and the Origin of Cutaneous Structures

Melanosomal sequestration of cytotoxic drugs contributes to the intractability of malignant melanomas, 2006

Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma. 2009

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