Purines and Pyrimidines Synthesis
Nucleic Acids Metabolism

Author: Gianpiero Pescarmona
Date: 18/03/2007

2011-02-23T11:19:26 - Gianpiero Pescarmona

The relationship between purines, pyrimidines, nucleosides, and glutamine for fibroblast cell proliferation. 1984


Synthesis of glutamine, glycine and 10-formyl tetrahydrofolate is coregulated with purine biosynthesis in Saccharomyces cerevisiae, 1998

Glutamine, glycine and 10-formyl tetrahydrofolate are consumed during de novo purine biosynthesis. We have found that, in Saccharomyces cerevisiae, synthesis of these cosubstrates is coregulated with synthesis of enzymes of the purine biosynthetic pathway. Analysis of three genes required for synthesis of glutamine, glycine and 10-formyl tetrahydrofolate (GLN1, SHM2 and MTD1, respectively) shows that their expression is repressed by adenine and requires the transcription factors Bas1p and Bas2p. Northern analysis reveals that regulation of SHM2 and MTD1 expression by adenine takes place at the transcriptional level.

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