Author: Gianpiero Pescarmona
Three distinct roles of aquaporin-4 in brain function revealed by knockout mice, 2006
AQP4 is involved in cerebral water balance, astrocyte migration, and neural signal transduction.
We found that AQP4-overexpression is likely triggered by hypoxia
Immunization of mice with a peptide derived from the HTLV-1 TAX1BP1 protein induces cross-reactive antibodies against aquaporin 4.
Inhibition of NMDA Receptors Downregulates Astrocytic AQP4
AQP4 is able to induce an autoreactive T cell response
ependyma, 3rd ventricle
Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice
Aquaporin-4 and brain edema
Congenital hypopituitarism in female infants. Its association with hypoglycemia and hypothyroidism. 1979
Congenital hypopituitarism was found in two female infants who had profound hypoglycemia and hypothyroidism.
Feedback regulation of thyrotropin-releasing hormone (TRH): mechanisms for the non-thyroidal illness syndrome. 2004
In contrast, central hypothyroidism associated with infection may be due to upregulation of type 2 deiodinase activity in tanycytes, specialized glial cells that line the infralateral walls and floor of the third ventricle.