Coenzyme A

Author: Gianpiero Pescarmona
Date: 11/08/2013


Coenzyme A is a coenzyme, notable for its role in the synthesis and oxidation of fatty acids, and the oxidation of pyruvate in the citric acid cycle.

All genomes sequenced to date encode enzymes that use coenzyme A as a substrate, and around 4% of cellular enzymes use it (or a thioester, such as acetyl-CoA) as a substrate.
In humans, CoA biosynthesis requires:

  • cysteamine
  • pantothenate
  • adenosine triphosphate.
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