Author: Gianpiero Pescarmona
The role of CNS fuel sensing in energy and glucose regulation. 2007
In particular, we suggest that in specific hypothalamic neurons, evolutionarily conserved fuel sensors, such as adenosine monophosphate-activated protein kinase and mammalian target of rapamycin ( mTOR ), integrate sensory input from nutrients, including those derived from recently ingested food or those that are stored in adipose tissue, to regulate effector pathways responsible for fuel intake and utilization.
Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase. 2007