DEFINITION
A short protein description with the molecular wheight, isoforms, etc...
The SGLT family comprises Na+-dependent:
- glucose co-transporters (SGLT1 and SGLT2),
- the glucose sensor SGLT3,
- the widely distributed inositol and multivitamin transporters SGLT4 and SGLT6,9
- the thyroid iodide transporter SGLT5.
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THE GENE
CHEMICAL STRUCTURE AND IMAGES
When relevant for the function
- Primary structure
- Secondary structure
- Tertiary structure
- Quaternary structure
Protein Aminoacids Percentage (xls file)
SYNTHESIS AND TURNOVER
mRNA synthesis
protein synthesis
post-translational modifications
degradation
CELLULAR FUNCTIONS
cellular localization,
biological function
Inhibitors of SGLT2
Role of Adenosine vasoconstriction
from. Metabolic control of kidney function II. Partial oxygen pressure (pO2) is lower in renal medulla than cortex, exposing the medulla to a greater risk for hypoxic damage. A concept is proposed that integrates the actions of extracellular adenosine (ADO) in the different regions of the kidney with respect to a protection of the medulla from hypoxic damage. The line plots illustrate the relationships between the given parameters. Small circles on these lines indicate ambient physiological conditions. 1, A rise in GFR increases the Na load (FNa) to the tubular system in cortex and medulla. This increases the salt concentration sensed by the macula densa ([Na-Cl-K]MD)(2), which enhances local ADO (3). 4, ADO lowers GFR and thus FNa, which closes a negative-feedback circle providing a basis for an oscillating system. 5, FNa determines Na transport work (TNa) and O2 consumption in every nephron segment, and thus oscillations in FNa may help protect the medulla. 6, A rise in TNa increases ADO along the nephron. 7, In the cortical proximal tubule, ADO stimulates TNa and thus lowers the Na load to segments residing in the medulla. 8, In contrast, ADO inhibits transport work in the medulla including medullary thick ascending limb (mTAL) and inner medullary collecting duct (IMCD). 9, In addition, ADO enhances medullary blood flow (MBF), which increases O2 delivery and further limits O2 consuming transport in the medulla.
Osmolarity
- Cell signaling and Ligand transport
- Structural proteins
REGULATION
DIAGNOSTIC USE
Vertical sleeve gastrectomy lowers kidney SGLT2 expression in the mouse, 2019
