Inositol, (of which the most prominent naturally-occurring form is myo-inositol, cis-1,2,3,5-trans-4,6-cyclohexanehexol), is a carbocyclic polyol that plays an important role as the structural basis for a number of secondary messengers in eukaryotic cells W
Inositol endogenous synthesis (Kegg Pathways)
Myo-Inositol is synthesized from glucose-6-phosphate (G-6-P) in two steps. First, G-6-P is isomerised by INYNA1 to myo-inositol 1-phosphate, which is then dephosphorylated by IMPA1 to give myo-inositol.
The synthesis of inositol requires oxidized nicotinamide adenine dinucleotide (NAD) and was stimulated by NH4C1 and MgC12. NADH inhibits the reaction. Phosphorylated inositol accumulated in the absence of MgC12, suggesting that inositol-phosphate is an intermediate in the pathway and that Mg ions stimulate the dephosphorylation of inositol-phosphate.
Inositol uptake from the diet
Uptake is a Na+-dependent process and it is inhibited by high glucose (20 mM).
myo-Inositol Phosphates synthesis
inositol phosphates during cell cycle 2007
IP3
The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasis.
2007