Heme Dependent Signaling
Signaling Pathways

Heme information content

Heme synthesis requires:

• Glycine (from proteins and glucose)
• Succinyl-CoA (from glucose)
• Estrogens
• PALP (from Vitamin B6)
• absence of Pb
• GSH (Effect of reduced glutathione on haem synthesis in rat liver during the postnatal period, 1966)
• 
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Heme synthesis localization

Heme transport

Heme Salvage Pathways

Heme Degradation

Heme as H2S and CO Sensor

Heme as NO Scavenger

• Candida hyphal growth
• Cancer Growth (in the direction of blood vessels)
  • NO scavenging
  • Nutrients source (phosphate, glucose, fibrinogen)

Heme and myelin synthesis

file	user	date
GSH_heme_synthesis_1966.jpg	gp	04/06/2021
GSH_increases_heme_synthesis_1966.pdf	gp	04/06/2021