Author: Gianpiero Pescarmona Date: 02/04/2021
TNF-α and hypoglycemia
Dexamethasone attenuates hypoglycemia in ten day old rats treated with TNF alpha. 1996
TNF alpha induced hypoglycemia and lactacidemia without altering plasma insulin concentration in 10 day old rats.
Parallel relationship between the increase in serotonin in the liver and the hypoglycaemia induced in mice by interleukin-1 and tumour necrosis factor. 1991
In the present study, it was found that the cytokines produced by macrophages in response to LPS, interleukin-1 (IL-1, 0.1 microgram/kg or more) and tumour necrosis factor (TNF alpha, 100 micrograms/kg or more), can also induce an increase in liver serotonin and produce hypoglycaemia.
