Cercare su Pubmed (Geo Profiles) come viene regolata l'espressione della mesothelin (IFN gamma e Dexamethasone)
E' una proteina legata alla membrana con una GPI anchor come il CEA
vedi le somiglianze
Papers Mesothelin and CEA
Sequence MSLN_HUMAN (630 residues):
Matching pattern PS00024 HEMOPEXIN:
317: FYKKWELEACVDAAL
Total matches: 1
Total no of hits in this sequence: 1
It matches also most MMPs
Papers Mesothelioma and CEA
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Search Prosite DB for Patterns in a PS
Selected Sequence(s)
# Mesothelin precursor (Pre-pro-megakaryocyte-potentiating factor) (CAK1 antigen) [Contains: Megakaryocyte-potentiating factor (MPF)_ Mesothelin, cleaved form] [Homo sapiens (Human)]
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Mesothelin precursor (Pre-pro-megakaryocyte-potentiating factor) (CAK1 antigen) [Contains: Megakaryocyte-potentiating factor (MPF)_ Mesothelin, cleaved form] [Homo sapiens (Human)]
Access# From->To Name Doc#
_______ ________ ____________________ _________
PS00001 57->61 ASN_GLYCOSYLATION PDOC00001
PS00001 388->392 ASN_GLYCOSYLATION PDOC00001
PS00001 496->500 ASN_GLYCOSYLATION PDOC00001
PS00001 523->527 ASN_GLYCOSYLATION PDOC00001
PS00005 5->8 PKC_PHOSPHO_SITE PDOC00005
PS00005 62->65 PKC_PHOSPHO_SITE PDOC00005
PS00005 79->82 PKC_PHOSPHO_SITE PDOC00005
PS00005 275->278 PKC_PHOSPHO_SITE PDOC00005
PS00005 280->283 PKC_PHOSPHO_SITE PDOC00005
PS00005 304->307 PKC_PHOSPHO_SITE PDOC00005
PS00005 394->397 PKC_PHOSPHO_SITE PDOC00005
PS00006 41->45 CK2_PHOSPHO_SITE PDOC00006
PS00006 178->182 CK2_PHOSPHO_SITE PDOC00006
PS00006 243->247 CK2_PHOSPHO_SITE PDOC00006
PS00006 275->279 CK2_PHOSPHO_SITE PDOC00006
PS00006 334->338 CK2_PHOSPHO_SITE PDOC00006
PS00006 380->384 CK2_PHOSPHO_SITE PDOC00006
PS00006 390->394 CK2_PHOSPHO_SITE PDOC00006
PS00006 421->425 CK2_PHOSPHO_SITE PDOC00006
PS00006 453->457 CK2_PHOSPHO_SITE PDOC00006
PS00006 543->547 CK2_PHOSPHO_SITE PDOC00006
PS00006 600->604 CK2_PHOSPHO_SITE PDOC00006
PS00007 479->486 TYR_PHOSPHO_SITE PDOC00007
PS00007 353->361 TYR_PHOSPHO_SITE PDOC00007
PS00008 171->177 MYRISTYL PDOC00008
PS00008 174->180 MYRISTYL PDOC00008
PS00008 186->192 MYRISTYL PDOC00008
PS00008 266->272 MYRISTYL PDOC00008
PS00008 509->515 MYRISTYL PDOC00008
PS00008 585->591 MYRISTYL PDOC00008
PS00008 588->594 MYRISTYL PDOC00008
PS00009 304->308 AMIDATION PDOC00009
PS00029 101->123 LEUCINE_ZIPPER PDOC00029
checking 63 PROSITE DNA binding motifs:
Leucine zipper pattern (PS00029): *** found ***
LRCLAHRLSEPPEDLDALPLDL at 101
