Biochemistry Group
2011
Modulation of doxorubicin resistance by the glucose 6-phosphate dehydrogenase activity
Manuela Polimeni, Claudia Voena, Joanna Kopecka, Chiara Riganti, Gianpiero Pescarmona, Amalia Bosia and Dario Ghigo
Biochem. J. (2011) Immediate Publication, doi:10.1042/BJ20102016
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2010
Glioblastoma cancer stem cells: heterogeneity, microenvironment and related therapeutic strategies.
Denysenko T, Gennero L, Roos MA, Melcarne A, Juenemann C, Faccani G, Morra I, Cavallo G, Reguzzi S, Pescarmona G, Ponzetto A.
Cell Biochem Funct. 2010 Jun 10.
PMID: 20535838 Fulltext
Altered nitric oxide/cGMP platelet signaling pathway in platelets from patients with acute coronary syndromes.
Bergandi L, Cordero M, Anselmino M, Ferraro G, Ravera L, Dalmasso P, Moiraghi C, Trevi GP, Ghigo D, Bosia A, Bergerone S.
Clin Res Cardiol. 2010 May 14. [Epub ahead of print]
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Does vitreous silica contradict the toxicity of the crystalline silica paradigm?
Ghiazza M, Polimeni M, Fenoglio I, Gazzano E, Ghigo D, Fubini B.
Chem Res Toxicol. 2010 Mar 15;23(3):620-9.
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Unacylated ghrelin rescues endothelial progenitor cell function in individuals with type 2 diabetes.
Togliatto G, Trombetta A, Dentelli P, Baragli A, Rosso A, Granata R, Ghigo D, Pegoraro L, Ghigo E, Brizzi MF.
Diabetes. 2010 Apr;59(4):1016-25.
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Fluoride-containing bioactive glasses inhibit pentose phosphate oxidative pathway and glucose 6-phosphate dehydrogenase activity in human osteoblasts.
Bergandi L, Aina V, Garetto S, Malavasi G, Aldieri E, Laurenti E, Matera L, Morterra C, Ghigo D.
Chem Biol Interact. 2010 Feb 12;183(3):405-15. Epub 2009 Nov 27.
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The Role of Circulating Bone Cell Precursors in Fracture Healing.
D'Amelio P, Cristofaro MA, Grimaldi A, Ravazzoli M, Pluviano F, Grosso E, Pescarmona GP, Isaia GC.
Calcif Tissue Int. 2010 Apr 14. [Epub ahead of print]
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Pluripotent plasticity of stem cells and liver repopulation.
Gennero L, Roos MA, Sperber K, Denysenko T, Bernabei P, Calisti GF, Papotti M, Cappia S, Pagni R, Aimo G, Mengozzi G, Cavallo G, Reguzzi S, Pescarmona GP, Ponzetto A.
Cell Biochem Funct. 2010 Mar 16. Local Fulltext
Mitochondrial Localization of Vitamin D Receptor in Human Platelets and Differentiated Megakaryocytes Silvagno F, De Vivo E, Attanasio A, Gallo V, Mazzucco G, Pescarmona GP
PLoS One. 2010 Jan 13;5(1):e8670.
Iron metabolism markers and haptoglobin phenotypes in susceptibility to HSV-1 or/and HSV-2 lesion relapses.
Gennero L, Roos MA, D'Amelio P, Denysenko T, Morra E, Sperber K, Ceroni V, Panzone M, Lesca F, De Vivo E, Grimaldi A, Gabetti ML, Ponzetto A, Pescarmona GP, Pugliese A.
Cell Biochem Funct. 2010 Jan 19.
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2009
iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells.
De Boo S, Kopecka J, Brusa D, Gazzano E, Matera L, Ghigo D, Bosia A, Riganti C.
Mol Cancer. 2009 Nov 19;8:108.
PMID: 19925669
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Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis
I Campia, C Lussiana, G Pescarmona, D Ghigo, A Bosia and C Riganti
Br J Pharmacol. 2009 Dec;158(7):1777-86. Epub .
PMID: 19888963
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Zoledronic acid repolarizes tumor-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway.
Coscia M, Quaglino E, Iezzi M, Curcio C, Pantaleoni F, Riganti C, Holen I, Mönkkönen H, Boccadoro M, Forni G, Musiani P, Bosia A, Cavallo F, Massaia M.
J Cell Mol Med. 2009 Oct 10. [Epub ahead of print]
PMID: 19818098
Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1alpha in human colon cancer cells.
Riganti C, Campia I, Polimeni M, Pescarmona G, Ghigo D, Bosia A.
Toxicol Appl Pharmacol. 2009 Jul 30. [Epub ahead of print]
PMID: 19647009
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Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression.
Riganti C, Doublier S, Viarisio D, Miraglia E, Pescarmona G, Ghigo D, Bosia A.
Br J Pharmacol. 2009 Mar 9. Fulltext
Digoxin and ouabain increase the synthesis of cholesterol in human liver cells.
Campia I, Gazzano E, Pescarmona G, Ghigo D, Bosia A, Riganti C.
Cell Mol Life Sci. 2009 Mar 15.
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The enzymatic activity of 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase is enhanced by NPM-ALK: new insights in ALK-mediated pathogenesis and the treatment of ALCL.
Boccalatte FE, Voena C, Riganti C, Bosia A, D'Amico L, Riera L, Cheng M, Ruggeri B, Jensen ON, Goss VL, Lee K, Nardone J, Rush J, Polakiewicz RD, Comb MJ, Chiarle R, Inghirami G.
Blood. 2009 Mar 19;113(12):2776-90.
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Targeted knowledge:interaction and rich user experience towards a scholarly communication that “lets”
Pescarmona GP, Giglia E
ELPUB 2009, Milan, 10-12 June 2009
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The Pinball Machine and the Cloud:Using Rules to move from Information to Knowledge
Pescarmona GP, Zamuner F, Giglia E
Third Italian IA Summit, Forlì, 20-21 february 2009
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2008
RhoA silencing reverts the resistance to doxorubicin in human colon cancer cells.
Doublier S, Riganti C, Voena C, Costamagna C, Aldieri E, Pescarmona G, Ghigo D, Bosia A.
Mol Cancer Res. 2008 Oct;6(10):1607-20.
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Role of iron metabolism and oxidative damage in postmenopausal bone loss.
D'Amelio P, Cristofaro MA, Tamone C, Morra E, Di Bella S, Isaia G, Grimaldi A, Gennero L, Gariboldi A, Ponzetto A, Pescarmona GP, Isaia GC., Bone. 2008 Dec;43(6):1010-5. PDF , Local PDF
Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells.
Riganti C, Doublier S, Costamagna C, Aldieri E, Pescarmona G, Ghigo D, Bosia A.
Mol Pharmacol. 2008 Aug;74(2):476-84. Epub 2008 May 7.
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The NADPH oxidase inhibitor apocynin induces nitric oxide synthesis via oxidative stress.
Riganti C, Costamagna C, Doublier S, Miraglia E, Polimeni M, Bosia A, Ghigo D.
Toxicol Appl Pharmacol. 2008 May 1;228(3):277-85.
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Asbestos induces doxorubicin resistance in MM98 mesothelioma cells via HIF-1alpha.
Riganti C, Doublier S, Aldieri E, Orecchia S, Betta PG, Gazzano E, Ghigo D, Bosia A.
Eur Respir J. 2008 Aug;32(2):443-51. Epub 2008 Apr 2.
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Quartz inhibits glucose 6-phosphate dehydrogenase in murine alveolar macrophages.
Polimeni M, Gazzano E, Ghiazza M, Fenoglio I, Bosia A, Fubini B, Ghigo D.
Chem Res Toxicol. 2008 Apr;21(4):888-94. Epub 2008 Mar 28.
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Estrogen deficiency increases osteoclastogenesis up-regulating T cells activity: a key mechanism in osteoporosis.
D'Amelio P, Grimaldi A, Di Bella S, Brianza SZ, Cristofaro MA, Tamone C, Giribaldi G, Ulliers D, Pescarmona GP, Isaia G.
Bone. 2008 Jul;43(1):92-100. Epub 2008 Mar 7.
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Risedronate reduces osteoclast precursors and cytokine production in postmenopausal osteoporotic women.
D'Amelio P, Grimaldi A, Di Bella S, Tamone C, Brianza SZ, Ravazzoli MG, Bernabei P, Cristofaro MA, Pescarmona GP, Isaia G.
J Bone Miner Res. 2008 Mar;23(3):373-9.
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Resistance to the nitric oxide/cyclic guanosine 5'-monophosphate/protein kinase G pathway in vascular smooth muscle cells from the obese Zucker rat, a classical animal model of insulin resistance: role of oxidative stress.
Russo I, Del Mese P, Doronzo G, Mattiello L, Viretto M, Bosia A, Anfossi G, Trovati M.
Endocrinology. 2008 Apr;149(4):1480-9.
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2007
Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition.
Riganti C, Orecchia S, Silvagno F, Pescarmona G, Betta PG, Gazzano E, Aldieri E, Ghigo D, Bosia A.
Am J Respir Cell Mol Biol. 2007 Jun;36(6):746-56. Epub 2007 Feb 22.
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Long-term exposure to dehydroepiandrosterone affects the transcriptional activity of the glucocorticoid receptor.
Saponaro S, Guarnieri V, Pescarmona GP, Silvagno F.
J Steroid Biochem Mol Biol. 2007 Feb;103(2):129-36. Epub 2006 Oct 27.
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Absence of soluble CD14 in saliva of young patients with dental caries.
Bergandi L, Defabianis P, Re F, Preti G, Aldieri E, Garetto S, Bosia A, Ghigo D
Eur J Oral Sci. 2007 Apr;115(2):93-6.
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Cytotoxicity of zinc-containing bioactive glasses in contact with human osteoblasts.
Aina V, Perardi A, Bergandi L, Malavasi G, Menabue L, Morterra C, Ghigo D.
Chem Biol Interact. 2007 May 1;167(3):207-18.
The Evolutionary Advantage of Being Conservative: The Role of Hysteresis. Pescarmona GP
In: DELSANTO, PIER PAOLO. Universality of Nonclassical Nonlinearity Applications to Non-Destructive Evaluations and Ultrasonics. p. 101-118, New York: Springer, ISBN/ISSN: 978-0-387-33860-6
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2006
Immune system and bone metabolism: Does thymectomy influence postmenopausal bone loss in humans?
D'Amelio P, Grimaldi A, Bernabei P, Pescarmona GP, Isaia G.
Bone. 2006 Sep;39(3):658-65. Epub 2006 May 11.
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Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma.
Riganti C, Orecchia S, Pescarmona G, Betta PG, Ghigo D, Bosia A.
Int J Cancer. 2006 Jul 1;119(1):17-27.
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2005
Analysis and Prototyping of Biological Systems: the Abstract Biological Process Model.
DI LEVA A, BERCHI R, PESCARMONA GP, SONNESSA M (2005).
INTERNATIONAL JOURNAL OF INFORMATION TECHNOLOGY, vol. 2; p. 216-224, ISSN: 1305-2403
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Analysis and Prototyping of Biological Systems.
DI LEVA A, BERCHI R, PESCARMONA GP, SONNESSA M (2005).
ENFORMATIKA, vol. 10; p. 1-6, ISSN: 1305-5313
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2004
Aldieri E, Orecchia S, Ghigo D, Bergandi L, Riganti C, Fubini B, Betta PG, Bosia A.
Simian virus 40 infection down-regulates the expression of nitric oxide synthase in human mesothelial cells.
Cancer Res. 2004 Jun 15;64(12):4082-4.
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2003
Bergandi L, Silvagno F, Russo I, Riganti C, Anfossi G, Aldieri E, Ghigo D, Trovati M, Bosia A.
Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells.
Arterioscler Thromb Vasc Biol. 2003 Dec;23(12):2215-21.
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Riganti C, Aldieri E, Bergandi L, Tomatis M, Fenoglio I, Costamagna C, Fubini B, Bosia A, Ghigo D.
Long and short fiber amosite asbestos alters at a different extent the redox metabolism in human lung epithelial cells.
Toxicol Appl Pharmacol. 2003 Nov 15;193(1):106-15. [Fulltext]
Riganti C, Aldieri E, Bergandi L, Miraglia E, Costamagna C, Bosia A, Ghigo D.
Nitroarginine methyl ester and canavanine lower intracellular reduced glutathione.
Free Radic Biol Med. 2003 Nov 15;35(10):1210-6. [Fulltext]
Aldieri E, Atragene D, Bergandi L, Riganti C, Costamagna C, Bosia A, Ghigo D.
Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation.
FEBS Lett. 2003 Sep 25;552(2-3):141-4. [Fulltext]
2002
Aldieri E, Bergandi L, Riganti C, Costamagna C, Bosia A, Ghigo D.
Doxorubicin induces an increase of nitric oxide synthesis in rat cardiac cells that is inhibited by iron supplementation.
Toxicol Appl Pharmacol. 2002 Dec 1;185(2):85-90. [Fulltext]
Riganti C, Aldieri E, Bergandi L, Fenoglio I, Costamagna C, Fubini B, Bosia A, Ghigo D.
Crocidolite asbestos inhibits pentose phosphate oxidative pathway and glucose 6-phosphate dehydrogenase activity in human lung epithelial cells.
Free Radic Biol Med. 2002 May 1;32(9):938-49. [Fulltext]
The life context: cells, nutrients and signals.
Pescarmona GP. In: CONDAT CA., BARUZZI A. Recent Research Development in Biophysical Chemistry. (pp. 69-90). TRIVANDRUM: RESEARCH SIGNPOST (INDIA) 2002
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2001
Revelli A, Bergandi L, Massobrio M, Lindblom B, Bosia A, Ghigo D.
The concentration of nitrite in seminal plasma does not correlate with sperm concentration, sperm motility, leukocytospermia, or sperm culture.
Fertil Steril. 2001 Sep;76(3):496-500. [Fulltext]
Local interaction simulation approach for the response of the vascular system to metabolic changes of cell behavior
Scalerandi, M., Pescarmona, G.P., Delsanto, P.P., Capogrosso Sansone, B. 2001
Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 63 (1 II), pp. 1-9
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2000
Analysis of a "phase transition" from tumor growth to latency
Delsanto, P.P., Romano, A., Scalerandi, M., Pescarmona, G.P. 2000
Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics 62 (2 B), pp. 2547-2554
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A physical-based model for the simulation of neoplastic growth and metastasis
Magnano, M., Bongioannini, G., Lerda, W., Galvagno, M.B., Tondolo, E., Canale, G., Capogrosso, B., , Pescarmona, G.P. 2000
Journal of Surgical Oncology 74 (2), pp. 122-129
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1999
Non-linear model of cancer growth and metastasis: A limiting nutrient as a major determinant of tumor shape and diffusion
Pescarmona, G.P., Scalerandi, M., Delsanto, P.P., Condat, C.A. 1999
Medical Hypotheses 53 (6), pp. 497-503 10
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Nutrient competition as a determinant for cancer growth
Scalerandi, M., Romano, A., Pescarmona, G.P., Delsanto, P.P., Condat, C.A. 1999 Physical Review E - Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics 59 (2 PART B), pp. 2206-2217
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1998
Model for diffusion and competition in cancer growth and metastasis
Pescarmona, G.P., Scalerandi, M., Delsanto, P.P., Condat, C.A. 1998
Materials Research Society Symposium - Proceedings 489, pp. 217-232
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Movement of vesicles in eucariotic cells. Role of intravesicle protons as a fuel and modulation of their concentration by drugs or metabolic changes
Materials Research Society Symposium - Proceedings 489, pp. 205-210
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Patents
USE OF PARASYMPATHOLYTIC SUBSTANCES TO ENHANCE AND ACCELERATE STEM CELL DIFFERENTIATION, RELATED METHOD AND COMPOSITIONS 2007
ALBUMIN FOR TREATING CANCER AND A PHARMACEUTICAL COMPOSITION COMPRISING THE COMBINATION OF AN ANTI-NEOPLASTIC AGENT AND ALBUMIN 2007
DIFFERENTIATED IMMORTALISED CELL LINES CAPABLE OF PRODUCING ALBUMIN AND BLOOD COAGULATION FACTORS, METHODS OF PREPARING THEREOF FROM A LEUKAEMIA CELL LINE AND USES THEREOF 2006
CULTURE MEDIUM AND PHARMACEUTICAL COMPOSITION FOR REGENERATING CARTILAGE TISSUE, A METHOD, USES AND PRODUCTS RELATED THERETO 2006
VERFAHREN ZUR VERBESSERUNG DER LAGERFAEHIGKEIT VON TROMBOZYTENPRAEPARATEN 1986
