Aldo-keto reductase family 1 member C3 [EC:1.1.1.51]
Urinary Steroids

EC:1.1.1. is a large family of enzymes with broad specificity, and therefore is difficult to understand their real function (many substrates in different pathways)

EC:1.1.1.51

hsa00140 Steroid hormone biosynthesis: synthesis of testosterone (unmeasurable) and androstanediol (measurable)
hsa00590 Arachidonic acid metabolism: PGD2 degradation. If impaired higher PGD2 and PGJ2
PDG2 - Google Scholar
Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyΔ12–14 PGJ2, 2007

• Here, we provide definitive proof that 15d-PGJ2 is synthesized during mammalian inflammatory responses, and we highlight DP1 receptor activation as a potential antiinflammatory strategy. (????)

hsa00790 Folate biosynthesis: 6-pyruvoyl tetrahydrobiopterin reductase
hsa01100 Metabolic pathways
hsa04913 Ovarian steroidogenesis
hsa05208 Chemical carcinogenesis - reactive oxygen species

• Aldose reductase EC:1.1.1.200

• 6-pyruvoyl tetrahydropterin reductase. 1.1.1.220
  • Brenda Human liver 6-pyruvoyl tetrahydropterin reductase is biochemically and immunologically indistinguishable from aldose reductase

Polyol Pathway