Polyol Pathway
Glucose Metabolism

Author: Gianpiero Pescarmona
Date: 21/10/2007


In the polyol pathway glucose is reduced by aldose reductase to sorbitol. Sorbitol dehydrogenase can then oxidize sorbitol to fructose.

Aldose reductase has a wide specificity

  • Aldose Reductase
    /product="aldo-keto reductase family 1 member A1"

Brenda Human liver 6-pyruvoyl tetrahydropterin reductase is biochemically and immunologically indistinguishable from aldose reductase

Aldose reductase has a high Km for both Glucose and NADPH

Flow trough this pathway lead to low NADPH/NADP and high NADH/NAD ratio

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