Angiotensin
Renin-Angiotensin-Aldosterone System

Author: Gianpiero Pescarmona
Date: 12/04/2010

Description

DEFINITION

A short protein description with the molecular wheight, isoforms, etc...
Use, when available, the link to Wikipedia (Es Trypsin)

DatabaseLink
WikigenesAGT
GeneCards"AGT":

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

  • Primary structure
  • Secondary structure
  • Tertiary structure
  • Quaternary structure


Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Model (Width 600 px)

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis
post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

Angiotensin receptor activating autoantibodies (AT1-AAs) may underlie many features of preeclampsia. AT1-AAs from preeclamptic patients activate angiotensin receptors (AT1R) on the surface of many cell types and may be responsible for many features of this serious pregnancy disorder. We have shown that antibody-induced receptor activation results in the mobilization of intracellular calcium and the activation of many genes. We propose that AT1-AAs activate AT1 receptors by promoting receptor homodimerization (Dr. Rodney Kellems). ROS, reactive oxygen species. SMC, smooth muscle cells; EC, endothelial cells.

  • Structural proteins

REGULATION

DIAGNOSTIC USE

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