Coagulation Proteins Evolution
Coagulation

Initiation

• Intrinsic pathway (blood)
  • Factor XII
  • Factor XI
  • Factor IX
• Extrinsic pathway (tissue)
  • Factor VII (TFPI inhibits)
    • TFPI1
    • TFPI2

Fibrin Clot Formation Common Pathway

• Factor X (ATIII inhibits)
• Thrombin (Vit K) (ATIII inhibits)
  • ATIII
  • Fibrinogen
    • FIBA
    • FIBC
    • FIBG

Fibrin Clot Cross-linking

• Factor XIII
  • Factor XIIIa
  • Factor XIIIb

Local Regulation

• Factor V
• Factor VIII

Activators

• Thrombin

Inhibitors

• Protein C (Vit K)
  • Thrombomodulin
  • Protein S

Let's assume that the Glu/Gln ratio is a reliable marker of oxygen level in the environment when a protein appears for the first time.
According to this hypothesis due to evolutionary oxygen increase in the atmosphere the sequence of the proteins appearence should be:

Coagulation proteins ordered in ascending way according to Glu/Gln ratio

New research reveals oxygen's contributions to evolution 2006

As some coagulatory proteins are activated by post-translational modification Vitamin K -dependent, we checked also the behavior of proteins involved in bacterial synthesis of Vit. K or of human Co Q10, a structural and functional analog of Vit. K.

Proteins involved in Coenzyme Q/ Vit. K synthesis

COQ6 and COQ7 are human proteins involved in CoQ synthesis specific steps
MENB are proteins specific for bacterial Vitamin K synthesis

More details about O2 rise on a shorter time scale

O2 stepping increase
O2 stepping increase n.2
Oxygen rise and living organisms

file	user	date
coagulazione_glu_gln_ordinato.gif	gp	08/06/2010
glu-gln-con-vit-K--600.gif	gp	08/06/2010
glu-gln-ordinato-3.gif	gp	07/06/2010
5870_coagulazione_completa.gif	gp	03/06/2010
FAXIII-600.gif	gp	03/06/2010
coagulazione_completa.gif	gp	03/06/2010
evoluzione_ossigeno.gif	gp	03/06/2010