DEFINITION
Glutathione peroxidase (GPx) (EC 1.11.1.9) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. The biochemical function of glutathione peroxidase is to reduce different peroxides (H2O2, lipid peroxides) using GSH as a reducing agent.
2GSH + H2O2 → GSSG + 2H2O
Glutathione reductase then reduces the oxidized glutathione to complete the cycle:
GSSG + NADPH + H+ → 2 GSH + NADP+.
THE GENE
| Database | Link |
| HGNC | "GPX1": | "GPX2": | "GPX3": | "GPX4": | "GPX5": | "GPX6": | "GPX7": | "GPX8": |
| Uniprot | "GPX1": | "GPX2": | "GPX3": | "GPX4": | "GPX5": | "GPX6": | "GPX7": | "GPX8": |
CHEMICAL STRUCTURE AND IMAGES
When relevant for the function
- Primary structure
- Secondary structure
- Tertiary structure
- Quaternary structure
Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)
Protein Aminoacids Percentage (Width 700 px)
SYNTHESIS AND TURNOVER
mRNA synthesis
gpx and vitamin D
protein synthesis
post-translational modifications
degradation
CELLULAR FUNCTIONS
High Pb, low Se in the area around Bergamo
The local mask of Bergamo, highly representative of the local population.
Without Se you have a low activity of Thyreoperoxidase, Deiodinase and GPOX
GPX4
cellular localization,
biological function
- Cell signaling and Ligand transport
- Structural proteins
REGULATION
gpx+and+aromatase
DIAGNOSTIC USE
