Phenylalanine Hydroxylase (PAH)
Phenylalanine and Tyrosine

Author: Gianpiero Pescarmona
Date: 07/07/2009

Description

DEFINITION

A short protein description with the molecular wheight, isoforms, etc...
Use, when available, the link to Wikipedia (Es Trypsin)

External links not available on Wikipedia have to be added here

Database	Link
Wikigenes	URL
GeneCards	URL
iHOP	URL
OMIM	URL1 URL2

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

Primary structure
Secondary structure
Tertiary structure
Quaternary structure

Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis
post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

Enzymes

Mechanism

PAHdb

Estimation of Km values of enzymes requiring molecular O2 as a substrate 1981

Cell signaling and Ligand transport
Structural proteins

REGULATION

DIAGNOSTIC USE

Comments

2009-07-07T09:12:24 - Gianpiero Pescarmona

Plasma total biopterin and tetrahydrobiopterin levels of 10 normal controls and 10 patients with monopolar depression were measured with and without internal standard. The levels did not differ between the two methods. A significant increase of total biopterin levels and the lower ratio of tetrahydrobiopterin to total biopterin in the depressive phase were observed in the plasma of patients with depression compared to normal controls, and these changes in plasma biopterin tended to normalize in the remission phase.
Changes in Plasma Tetrahydrobiopterin Levels of Depressives in Depressive and Remission Phases: Reconfirmed by Measurement with an Internal Standard 1994