DEFINITION
A short protein description with the molecular wheight, isoforms, etc...
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THE GENE
CHEMICAL STRUCTURE AND IMAGES
When relevant for the function
- Primary structure
- Secondary structure
- Tertiary structure
- Quaternary structure
Protein Aminoacids Percentage
SYNTHESIS AND TURNOVER
mRNA synthesis
protein synthesis
post-translational modifications
degradation
CELLULAR FUNCTIONS
cellular localization,
Mechanisms of calnexin and calreticulin action as described by the “lectin-only” and “dual-binding” models. Details of the models are described in the text. ERp57 catalyzes disulfide bond formation and isomerization within the glycoprotein substrate via a mixed disulfide intermediate involving a substrate cysteine (-SH) and cysteines within the active site CGHC motifs of ERp57 (-S-S-).97
A model of the relationship between STAT3, ERp57, and calreticulin. This model shows cross-talk between ERp57, calreticulin, and STAT3 signaling. ERp57 forms functional complexes with calnexin and calreticulin to promote protein folding, disulfide bond formation, and isomerization. ERp57 is also critical for MHC class I biosynthesis and assembly. A model shows that ERp57, from the lumen of the ER, also affects STAT3 signaling and functions as a STAT3 inhibitor. ERp57-dependent modulation of STAT3 is enhanced by complex formation between ERp57 and calreticulin.
ERp57 Modulates STAT3 Signaling from the Lumen of the Endoplasmic Reticulum 2009
biological function
- Cell signaling and Ligand transport
- Structural proteins
REGULATION
DIAGNOSTIC USE
