MHC System
Immune System

Author: Gianpiero Pescarmona
Date: 10/03/2011



  • The major histocompatibility complex (MHC) is a set of cell surface proteins essential for the acquired immune system to recognize foreign molecules in vertebrates, which in turn determines histocompatibility. The main function of MHC molecules is to bind to antigens derived from pathogens and display them on the cell surface for recognition by the appropriate T-cells.

MHC I and MHC II interacts with different T cells

MHC Class I

MHC class II


  • HLA class II histocompatibility antigen gamma chain also known as HLA-DR antigens-associated invariant chain or CD74 (Cluster of Differentiation 74), is a protein that in humans is encoded by the CD74 gene. The invariant chain (Abbreviated Ii) is a polypeptide involved in the formation and transport of MHC class II protein.

Kegg Pathways

Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules, 2009

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