Calnexin and Calreticulin
MHC System

Author: Gianpiero Pescarmona
Date: 10/03/2011

Description

DEFINITION

A short protein description with the molecular wheight, isoforms, etc...
Use, when available, the link to Wikipedia (Es Trypsin)

External links not available on Wikipedia have to be added here

THE GENE

DatabaseLink
WikigenesCANXCALRERp57
GeneCards"URL":
Your Favorite Gene Sigma"URL":

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

  • Primary structure
  • Secondary structure
  • Tertiary structure
  • Quaternary structure

Protein Aminoacids Percentage

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis

post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,

Mechanisms of calnexin and calreticulin action as described by the “lectin-only” and “dual-binding” models. Details of the models are described in the text. ERp57 catalyzes disulfide bond formation and isomerization within the glycoprotein substrate via a mixed disulfide intermediate involving a substrate cysteine (-SH) and cysteines within the active site CGHC motifs of ERp57 (-S-S-).97

A model of the relationship between STAT3, ERp57, and calreticulin. This model shows cross-talk between ERp57, calreticulin, and STAT3 signaling. ERp57 forms functional complexes with calnexin and calreticulin to promote protein folding, disulfide bond formation, and isomerization. ERp57 is also critical for MHC class I biosynthesis and assembly. A model shows that ERp57, from the lumen of the ER, also affects STAT3 signaling and functions as a STAT3 inhibitor. ERp57-dependent modulation of STAT3 is enhanced by complex formation between ERp57 and calreticulin.

ERp57 Modulates STAT3 Signaling from the Lumen of the Endoplasmic Reticulum 2009
biological function

  • Enzymes
DatabaseLink
BRENDA - The Comprehensive Enzyme Information System"URL":
KEGG Pathways"URL":
Human Metabolome Database"URL":
  • Cell signaling and Ligand transport
  • Structural proteins

REGULATION

DIAGNOSTIC USE

Attachments
fileuserdate
CALX_CALR_PDIA3_ch1.gifgp10/03/2011
CALX_CALR_PDIA3_ch2.gifgp10/03/2011
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