Author: Gianpiero Pescarmona Date: 18/03/2007
Functions: endocytosis-and-exocytosis
The PrP recycling
Kegg Pathways: Lysosomes
The pH range of acidic vesicles
Citron kinase, a RhoA effector, enhances HIV-1 virion production by modulating exocytosis.
Overexpression of ROCK in human breast cancer cells: evidence that ROCK activity mediates intracellular membrane traffic of lysosomes.
Small guanosine triphosphatase Rho/Rho-associated kinase as a novel regulator of intracellular redistribution of lysosomes in invasive tumor cells.
Endogenously expressed HIV-1 nef down-regulates antigen-presenting molecules, not only class I MHC but also CD1a, in immature dendritic cells.
Endocytosis in viral replication.
The downregulation of CD4 and MHC-I by primate lentiviruses: a paradigm for the modulation of cell surface receptors.
Ion transport across transmembrane pores. . Endocytosis movies YouTube Endo- and Exocytosis movies Endo- and Exocytosis prof. Toid kirchhausen
The stoichiometry at the level of the membrane complex (Band3, GAPDH, Na+/H+ antiport, Iron reducing electrons carrier) is
As an example into erythrocytes Hb (4 Fe++) and DPG (2 Phosphate) are equimolar (around 5 mM) and the ratio Pin/Fe is 0,5 as expected in a cell in which the phosphate is not used for proliferation (DNA synthesis)
The sodium/hydrogen exchanger: A possible mediator of immunity 2006
Insulin activation of red blood cell Na+/H+ exchange decreases the affinity of sodium sites.
Protons gradient can be used to fuel many type of movement...... In both cases protons efflux requires ATP breakdown (directly or through a Na+ gradient created by Na+/K+ATPase)
Factors involved in cell movement:
Omeprazole and PTH
Additional material
Dubinsky model
Late endosomes migrano alla periferia se fuori pH 6.5 serini guido
