Author: Gianpiero Pescarmona Date: 29/07/2008
Colchicine is a highly poisonous natural product. Its present medicinal use is mainly in the treatment of gout; as well, it is being investigated for its potential use as an anti-cancer drug. It can also be used as initial treatment for pericarditis and preventing recurrences of the condition. In neurons, axoplasmic transport is disrupted by colchicine.
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Zinc and the cytoskeleton in the neuronal modulation of transcription factor NFAT. 2006
Disruption of microtubules leads to glucocorticoid receptor degradation in HeLa cell line.2005
In August 2009, colchicine won Food and Drug Administration (FDA) approval in the United States as a stand-alone drug for the treatment of acute flares of gout and familial Mediterranean fever
