Regulatory T cells , sometimes known as suppressor T cells, are a specialized subpopulation of T cells which suppresses activation of the immune system and thereby maintains tolerance to self-antigens.
Factors that have been described to be important for Treg induction within the tumor include TGF-b, IL-10, H-Ferritin (Gray CP, Arosio P, Hersey P. Heavy chain ferritin activates regulatory T cells by induction of changes in dendritic cells. Blood 2002;99:3326–34), IDO and Prostaglandin E2 (PGE2).9,20–22 These findings highlight the importance of
understanding the mechanisms of immune-escape in the tumor microenvironment.
Follicular lymphoma B cells induce the conversion of conventional CD41 T cells to T-regulatory cells
Treg cells glucocorticoids