Abscisic Acid
Phytochemicals

Author: Gianpiero Pescarmona
Date: 12/07/2009

Description

Abscisic acid (W) is often referred to as a inhibitory rather than stimulatory hormone.

ABA biosynthesis

Complete blockage of the mevalonate pathway results in male gametophyte lethality. 2009

Cytoplasmic isoprenoids (e.g. sterols and brassinosteroids) and mitochondrial isoprenoids (e.g. side chains of ubiquinone) are synthesized via the MVA pathway, while the MEP pathway is used to synthesize plastidic isoprenoids (e.g. carotenoids and the side chains of chlorophylls and plastoquinones) and some isoprenoid-type phytohormones (e.g. gibberellins, abscisic acid, and cytokinins).

ABA biosynthesis

Requirements: Mb, NAD+ (not NADP)

Gibberellins

It does so by inhibiting protein synthesis and dehydration processes.

ABA downstream effects

Target genes of ABA

CD38

More

Working hypothesis

NAD is released by Myt in:

  • hypoxia
  • hyperosmolarity

GERANYLGERANYLPIROPHOSPHATE is transformed to ABA that convertS NAD to cADPR

ABA and hypoxia

Sensitivity to ABA increasing and sensitivity to GA decreasing with hypoxia.
Quantifying the sensitivity of barley seed germination to oxygen, abscisic acid, and gibberellin using a population-based threshold model. 2008

ABA content remained constant after 48 h of incubation under air, while it increased dramatically in embryos incubated under hypoxia
Hypoxia interferes with ABA metabolism and increases ABA sensitivity in embryos of dormant barley grains. 2006

Nitric oxide signaling in plants. 2005

Comments
2012-05-15T14:16:13 - Gianpiero Pescarmona

DEFINITION

A short protein description with the molecular wheight, isoforms, etc...
Use, when available, the link to Wikipedia (Es Trypsin)

Abscisic acid human

ABA and LANCL2 interaction with MDR

LANCL2 drug


Myristoylation of human LanC-like protein 2 (LANCL2) is essential for the interaction with the plasma membrane and the increase in cellular sensitivity to adriamycin. 2006

Moreover, we confirmed previous data that LANCL2 overexpression enhances the cellular sensitivity to the anticancer drug adriamycin and found that this sensitivity is dependent on the myristoylation and membrane association of LANCL2.

THE GENE

DatabaseLink
WikigenesLANCL1LANCL2
GeneCards"LANCL1":"LANCL2":
Your Favorite Gene Sigma"LANCL1":"LANCL2":

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

  • Primary structure
  • Secondary structure
  • Tertiary structure
  • Quaternary structure


Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Protein Aminoacids Percentage (Width 700 px)

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis

post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

  • Enzymes
DatabaseLink
BRENDA - The Comprehensive Enzyme Information System"URL":
KEGG Pathways"URL":
Human Metabolome Database"URL":
  • Cell signaling and Ligand transport
  • Structural proteins

REGULATION

DIAGNOSTIC USE

Polished rice as natural sources of cancer-preventing geranylgeranoic acid. 2011

Attachments
fileuserdate
LANC1_LANC2.GIFgp15/05/2012
LANC1_LANC2.xlsgp15/05/2012
LANC1_LANC2_CH2.GIFgp15/05/2012
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