Depression
Diseases

Author: Gianpiero Pescarmona
Date: 2010-03-03T00:00:00

Description

DEFINITION

Depression is a term that can refer to a wide variety of abnormal variations in an individual's mood

Also the link to the corresponding Mesh term has to be created

DatabaseLink
Wikipedia"URL":
The Diseases Database"URL":
OMIM"URL":

EPIDEMIOLOGY

age, sex, seasonality, etc

SYMPTOMS

DIAGNOSIS

histopathology
radiology
NMR
laboratory tests

PATHOGENESIS

PATIENT RISK FACTORS

Vascular

Genetic

Acquired

Hormonal

Genetic

Acquired

TISSUE SPECIFIC RISK FACTORS

anatomical (due its structure)

vascular (due to the local circulation)

physiopathological (due to tissue function and activity)

COMPLICATIONS

Comments
2010-03-27 13:44:25.492795 - claudia bartoli

Correlation between depression and folic acid pahtways.

There are a lot of studies in the letterature about this point.
We have selected some examples:

Association between depressive symptoms and serum concentrations of homocysteine in men: a population study (2004)

The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis (2006)

Methylenetetrahydrofolate Reductase (MTHFR) Genetic Polymorphisms and Psychiatric Disorders: A HuGE Review (2007)

Homocysteine and Depression in Later Life (2008)

There is a current Australian trial that want to demonstrate the benifit of folic acid and B vitamin supplementation in the MDD terapy!!!!
The B-VITAGE trial: A randomized trial of homocysteine lowering treatment of depression in later life (2010)