Tinnitus (acuphenes)
Diseases

Author: Gianpiero Pescarmona
Date: 27/10/2010

Description

DEFINITION

Tinnitus (from the Latin word tinnītus meaning "ringing") is the perception of sound within the human ear in the absence of corresponding external sound.

DatabaseLink
The Diseases DatabaseTinnitus
MedlinePlusTinnitus
WikigenesTinnitus
GeneCardsTinnitus

Tinnitus

EPIDEMIOLOGY

age, sex, seasonality, etc

SYMPTOMS

DIAGNOSIS

histopathology
radiology
NMR
laboratory tests

PATHOGENESIS

PATIENT RISK FACTORS

Vascular

Genetic

Acquired

  • Vitamin B12, folate

Hormonal

Genetic

Acquired

Mechanical

Temporomandibular joint disfunction

tinnitus mandibular

Evaluation of pain regression in patients with temporomandibular dysfunction treated by intra-articular platelet-rich plasma injections: a preliminary report. 2014

the presence and intensity of spontaneous and palpation-induced pain within temporomandibular joints and masticatory muscles, the range and symmetry of mandible motion, abduction trajectory, and the presence of acoustic symptoms within temporomandibular joints during all mandible movements and accompanying symptoms such as squeaking sounds and tinnitus in ears.

DRUGS SIDE EFFECT

Identifying tinnitus-related genes based on a side-effect network analysis. 2014

  • Tinnitus, phantom sound perception, is a worldwide highly prevalent disorder for which no clear underlying pathology has been established and for which no approved drug is on the market. Thus, there is an urgent need for new approaches to understand this condition. We used a network pharmacology side-effect analysis to search for genes that are involved in tinnitus generation. We analyzed a network of 1,313 drug-target pairs, based on 275 compounds that elicit tinnitus as side effect and their targets reported in databases, and used a quantitative score to identify emergent significant targets that were more common than expected at random. Cyclooxigenase 1 and 2 were significant, which validates our approach, since salicylate is a known tinnitus generator. More importantly, we predict previously unknown tinnitus-related targets. The present results have important implications toward understanding tinnitus pathophysiology and might pave the way toward the design of novel pharmacotherapies.

Link to original figure

Aspirin

Benzodiazepines

Alcohol

Tinnitus alcoholism

TISSUE SPECIFIC RISK FACTORS

anatomical (due its structure)

vascular (due to the local circulation)

physiopathological (due to tissue function and activity)

COMPLICATIONS

THERAPY

MeSH
Comments
2013-01-19T14:47:59 - Gianpiero Pescarmona

Emocromo, Sideremia, ferritina, transferrina
Calcemia, Paratormone, 25(OH) VitD3
Creatinina, Acido urico, Velocita' Filtrazione Glomerulare (cVFG), esame completo urine.
TSH riflesso, colesterolo, colesterolo HDL, trigliceridi,
glicemia, creatinina, uricemia, Quadro Proteico elettroforetico, proteine totali, albumina
Sodiemia, Potassiemia
PCR, Fibrinogeno, VES,
Genetici (da fare una sola volta) Polimorfismi: MTHFR C677T e A1298C
omocisteina, folati, Vitamina B12
IgG e IgM anti CMV, Chlamidia, Parvovirus

AddThis Social Bookmark Button