Casein
Mammary Gland

DEFINITION

Casein (/ˈkeɪs.ɪn/ or /ˈkeɪˌsiːn/, from Latin caseus, "cheese") is the name for a family of related phosphoproteins (αS1, αS2, β, κ). These proteins are commonly found in mammalian milk, making up 80% of the proteins in cow milk and between 20% and 45% of the proteins in human milk. As a food source, casein supplies amino acids, carbohydrates, and the two inorganic elements calcium and phosphorus.

THE GENE

Database	Link	Link	Link
Wikigenes	CSNA1	CSN2	CASK
GeneCards	"URL":	"URL":	"URL":
Uniprot	CASA1	CASB	CASK

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

• Primary structure
• Secondary structure
• Tertiary structure
  • PDB
• Quaternary structure

Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Protein Aminoacids Percentage (Width 700 px)

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis

post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

Casein kappa

anti/tumor activity?

casein+kappa+cancer

• Lactaptin induces p53-independent cell death associated with features of apoptosis and autophagy and delays growth of breast cancer cells in mouse xenografts. 2014
  • Lactaptin, the proteolytic fragment of human milk kappa-casein, induces the death of various cultured cancer cells.

• Enzymes

Database	Link
BRENDA - The Comprehensive Enzyme Information System	"URL":
KEGG Pathways	"URL":
Human Metabolome Database	"URL":

• Cell signaling and Ligand transport
• Structural proteins

REGULATION

DIAGNOSTIC USE

file	user	date
Caseinabk_ch1.png	gp	16/03/2016
Caseinabk_ch2.png	gp	16/03/2016