Mesalazine
Drugs

DESCRIPTION

Mesalazine, also known as mesalamine (USAN) or 5-aminosalicylic acid (5-ASA), is an aminosalicylate anti-inflammatory drug used to treat inflammatory bowel disease, including ulcerative colitis, or inflamed anus or rectum, and to maintain remission in Crohn's disease.

CLASSIFICATION

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INDICATIONS

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PHARMACOKINETICS

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MOLECULAR MECHANISM

• mesalazine mechanism
• THE EFFECT OF SULFASALAZINE AND 5-AMINOSALICYLIC ACID ON THE SECRETION OF INTERLEUKIN 8 BY HUMAN COLON MYOFIBROBLASTS. 2015
  5-ASA mechanism of action on the one hand, involves the inhibition of the cyclooxygenase and lipoxygenase activity, and thus decrease of synthesis of prostaglandins, leukotrienes and free radicals, on the other hand, the suppression of the immune response in the intestinal mucosa.
• 5-Aminosalicylic acid inhibits inflammatory responses by suppressing JNK and p38 activity in murine macrophages. 2017
  CONTEXT 5-Aminosalicylic acid (5-ASA), as an anti-inflammatory drug, has been extensively used for the treatment of mild to moderate active ulcerative colitis (UC), but the possible mechanisms of action remain unclear.

Kolaviron, a Natural Antioxidant and Anti-Inflammatory Phytochemical Prevents Dextran Sulphate Sodium-Induced Colitis in Rats, 2013

Pharmacological Activity of 6-Gingerol in DextranSulphate Sodium-induced Ulcerative Colitis inBALB/c Mice, 2015
h3. PHARMACOGENOMICS

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SIDE EFFECTS

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TOXICITY

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RESISTANCE

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DEPENDENCE AND WITHDRAW