CD98 (Large Neutral Amino Acid Transporter)
Amino Acids Transporters

DEFINITION

CD98 is a glycoprotein that is a heterodimer composed of SLC3A2 (heavy subunit) and SLC7A5 ( light subunit) that forms the large neutral amino acid transporter (LAT1/LAT2).

LAT1/LAT2 is a heterodimeric membrane transport protein that preferentially transports branched-chain (valine, leucine, isoleucine) and aromatic (tryptophan, tyrosine) amino acids.

• LAT1 is highly expressed in brain capillaries (which form the blood–brain barrier) relative to other tissues.
• LAT2 is localized to the cytoplasm when expressed alone but when coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi.

THE GENE

Database	Link
HGNC	ACADM
Uniprot	"URL":

HGNC includes links to

• BioGPS
• GENATLAS
• GeneCards
• GOPubmed
• H-InvDB
• QuickGO
• Reactome
• Wikigenes includes links to
  • NCBI
  • NCBI SNP
  • iHOP resource
  • OMIM
  • UniProt
  • Ensembl
  • HGNC

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

• Primary structure
• Secondary structure
• Tertiary structure
  • PDB
• Quaternary structure

Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Protein Aminoacids Percentage (Width 700 px)

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis

post-translational modifications
degradation

CELLULAR FUNCTIONS

cellular localization,
biological function

• Enzymes

Database	Link
BRENDA - The Comprehensive Enzyme Information System	"URL":
KEGG Pathways	"URL":
Human Metabolome Database	"URL":

• Cell signaling and Ligand transport
• Structural proteins

REGULATION

DIAGNOSTIC USE