Glucocorticoids increase neutrophils number?
Decreased Lymphocytes and Increased Risk for Infection are Common in Endogenous Pediatric Cushing Syndrome, 2018
Which factors are involved in cross-talk between different lineages?
One of the key players in self-renewal and development of haematopoietic cells is stem cell factor (SCF), which binds to the c-kit receptor on the HSC. Absence of SCF is lethal. There are other important glycoprotein growth factors which regulate the proliferation and maturation, such as interleukins IL-2, IL-3, IL-6, IL-7. Other factors, termed colony-stimulating factors (CSFs), specifically stimulate the production of committed cells. Three CSFs are granulocyte-macrophage CSF (*GM-CSF*), granulocyte CSF (*G-CSF*) and macrophage CSF (*M-CSF*). These stimulate granulocyte formation and are active on either progenitor cells or end product cells.
Erythropoietin is required for a myeloid progenitor cell to become an erythrocyte. On the other hand, thrombopoietin makes myeloid progenitor cells differentiate to megakaryocytes (thrombocyte-forming cells). The diagram to the right provides examples of cytokines and the differentiated blood cells they give rise to.