Osteopontin
Osteopontin Shapes Immunosuppression in the Metastatic Niche. 2014
Matricellular proteins: from homeostasis to inflammation, cancer, and metastasis. 2010
The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. 2001
Comment on:The Influence of the Proinflammatory Cytokine, Osteopontin, on Autoimmune Demyelinating Disease, 2003
Molecular mechanisms linking wound inflammation and fibrosis: knockdown of osteopontin leads to rapid repair and reduced scarring.
Mori R, Shaw TJ, Martin P.
J Exp Med. 2008 Jan 21;205(1):43-51. Epub 2008 Jan 7.
Fulltext
Previous studies of tissue repair have revealed osteopontin (OPN) to be up-regulated in association with the wound inflammatory response. We hypothesize that OPN may contribute to inflammation-associated fibrosis. In a series of in vitro and in vivo studies, we analyze the effects of blocking OPN expression at the wound, and determine which inflammatory cells, and which paracrine factors from these cells, may be responsible for triggering OPN expression in wound fibroblasts. Delivery of OPN antisense oligodeoxynucleotides into mouse skin wounds by release from Pluronic gel decreases OPN protein levels at the wound and results in accelerated healing and reduced granulation tissue formation and scarring. To identify which leukocytic lineages may be responsible for OPN expression, we cultured fibroblasts in macrophage-, neutrophil-, or mast cell-conditioned media (CM), and found that macrophage- and mast cell-secreted factors, specifically platelet-derived growth factor (PDGF), induced fibroblast OPN expression. Correspondingly, Gleevec, which blocks PDGF receptor signaling, and PDGF-Rbeta-neutralizing antibodies, inhibited OPN induction by macrophage-CM. These studies indicate that inflammation-triggered expression of OPN both hinders the rate of repair and contributes to wound fibrosis. Thus, OPN and PDGF are potential targets for therapeutic modulation of skin repair to improve healing rate and quality.
Osteopontin expression in the liver with severe perisinusoidal fibrosis: autopsy case of Down syndrome with transient myeloproliferative disorder. 2008
Osteopontin expression in human and murine obesity: extensive local up-regulation in adipose tissue but minimal systemic alterations. 2008
The expression of osteopontin is increased in vessels with blood-brain barrier impairment. 2008
Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells. 2008
Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice. 2007
