Antagonistic effects of cAMP and cGMP on L-type calcium channels
cGMP and Ca2+ homeostasis
- cGMP direct effects on Ca2+ channel
- cGMP effects mediated by PKG activation.
- cGMP can activate Ca2+ influx, by a process involving PKG regulation of ion channels.
- It can also activate Ca2+ release from ryanodine-sensitive intracellular stores by a pathway involving PKG and cyclic ADP-ribose.
Cyclic GMP metabolism and its role in brain phisiology,K.D. Lopacinska,J Physiol Pharmacol. 2005