Author: Gianpiero Pescarmona
Novel animal-health drug targets from ligand-gated chloride channels 2002
Cardiac anion channels, transport and exchange proteins and their intracellular signaling pathways (from Hume et al., Physiol. Rev. 80: 31-81, 2000)
Intracellular ClC-3 chloride channels promote bone resorption in vitro through organelle acidification in mouse osteoclasts 2008
The cannabinoid WIN 55,212-2 inhibits transient receptor potential vanilloid 1 (TRPV1) and evokes peripheral antihyperalgesia via calcineurin.
Ion Channel Cell Lines
ChanTest are currently building what is planned to become the largest collection of fully validated stable cell lines expressing ion channel targets. These cell lines are now available to license for your own internal research purposes as well as being accessible via custom screening services.
The cell line collection is growing rapidly and will soon contain all of the following ion channel types:
* Sodium Channel Family
* Potassium Channel Family
* Calcium Channel Family
* TRP Channel Family
* Ligand-Gated Channels
Click here to see the list of cell lines that have been developed to-date.