b. Protein Degradation

Author: Gianpiero Pescarmona
Date: 30/05/2009


Metalloproteinases (or metalloproteases) constitute a family of enzymes from the group of proteinases, classified by the nature of the most prominent functional group in their active site. These are proteolytic enzymes whose catalytic mechanism involves a metal. Most metalloproteases are zinc-dependent, some use cobalt. The metal ion is coordinated to the protein via three Histadine imidazole ligands. The fourth coordination position is taken up by a labile water molecule.

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