Helicobacter Pylori - Virulence Factors
Bacterial Specificity

Author: Edoardo Manca
Date: 28/03/2012

Description

1) Virulence Factors:

1
HP Antigens

A. Urease

1
Living Dangerously: How Helicobacter Pylori survives in the human stomach - Montecucco, Rappuoli - Nature, 2001
2
Structure of HP urease

B. Adhesins

1
Helicobacter pylori in Health and Disease - Cover, Blaser - Gastroenterology, 2009

C. CagA and HP Type IV secretion system

1
Helicobacter pylori in Health and Disease – Cover, Blaser – Gastroenterology, 2009
2
Living Dangerously: How Helicobacter Pylori survives in the human stomach - Montecucco, Rappuoli - Nature,2001
3
CagA protein of Helicobacter pylori: a hijacker of gastric epithelial cell signaling. - Handa, Naito, Yoshikawa - Biochem Pharmacol.,2007
4
A tale of two toxins: Helicobacter pylori CagA and VacA modulate host pathways that impact disease - Kathleen R. Jones, Jeannette M. Whitmire and D. Scott Merrell - Frontiers in Microbiology,2010

D. VacA

1
Helicobacter pylori in Health and Disease - Cover, Blaser - Gastroenterology, 2009
2
Molecular and cellular mechanisms of action of the vacuolating cytotoxin (VacA) and neutrophil-activating protein (HP-NAP) virulence factors of Helicobacter pylori - Montecucco, de Bernard - Microbes Infect, 2003
3
A tale of two toxins: Helicobacter pylori CagA and VacA modulate host pathways that impact disease - Kathleen R. Jones, Jeannette M. Whitmire and D. Scott Merrell - Frontiers in Microbiology, 2010

E. HP-NAP

1a,b
Helicobacter pylori, asthma and allergy - D’Elios, Codolo, Amedei, Mazzi, Berton, Zanotti, Del Prete, de Bernard - FEMS Immunol Med Microbiol, 2009
1c - 2
Structure of the Neutrophil-activating Protein from Helicobacter pylori - Zanotti, Papinutto, Dundon, Battistutta, Seveso, Del Giudice, Rappuoli, Montecucco - J. Mol. Biol., 2002
3
Molecular and cellular mechanisms of action of the vacuolating cytotoxin (VacA) and neutrophil-activating protein (HP-NAP) virulence factors of Helicobacter pylori - Montecucco, de Bernard - Microbes Infect, 2003
4
The neutrophil-activating protein of Helicobacter pylori (HP-NAP) as an immunemodulating agent - D’Elios, Amedei, Cappon, Del Prete, Marina de Bernard - FEMS Immunol Med Microbiol, 2007

2) Consequences of HP colonization:

I. Tight junctions disruption

1
Targeted disruption of the epithelial-barrier by Helicobacter pylori - Wroblewski, Peek Jr - Cell Communication and Signaling, 2011

II. Gastritis, Peptic Ulcer, Oxidative Stress, Chronic Inflammation and Indirect Cancerogenicity

1
Progression of HP gastric colonization
2
Living Dangerously: How Helicobacter Pylori survives in the human stomach - Montecucco, Rappuoli - Nature, 2001
3
Pathogenesis of HP infection
4
Histological image of gastric mucosa
5
CagA protein of Helicobacter pylori: a hijacker of gastric epithelial cell signaling. - Handa, Naito, Yoshikawa - Biochem Pharmacol., 2007
6
The immune modulating activity of the Helicobacter pylori HP-NAP: Friend or foe? - de Bernard, D’Elios - Toxicon, 2010
7
Caspase-1 Has Both Pro-Inflammatory and Regulatory Properties in Helicobacter Infections, Which Are Differentially Mediated by Its Substrates IL-1β and IL-18 - Hitzler, Sayi, Kohler, Engler, Koch, Hardt, Müller - J Immunol., 2012

III. Immune Modulation

1
Helicobacter pylori, asthma and allergy - D’Elios, Codolo, Amedei, Mazzi, Berton, Zanotti, Del Prete, de Bernard - FEMS Immunol Med Microbiol, 2009
2
Th1 and Th2 cells
3-6
The effect of Helicobacter pylori on asthma and allergy - Amedei, Codolo, Del Prete, de Bernard, D'Elios - J Asthma Allergy, 2010
4
The neutrophil-activating protein of Helicobacter pylori (HP-NAP) as an immunemodulating agent - D’Elios, Amedei, Cappon, Del Prete, Marina de Bernard - FEMS Immunol Med Microbiol, 2007
5
Association Between Helicobacter pylori Infection and Inflammatory Bowel Disease: A Meta-analysis and Systematic Review of the Literature - Luther, Dave, Higgins, Kao - Inflamm Bowel Dis, 2010

IV. Iron Trafficking Perturbation

- Indirect mechanisms

1
Unique Host Iron Utilization Mechanisms of Helicobacter pylori Revealed with Iron-Deficient Chemically Defined Media - Senkovich, Ceaser, McGee, Testerman - Infection and Immunity, 2010

- Direct mechanisms

1-2
Transferrin Receptors
3-[ 4 ]
Alternative Splicing Regulates the Subcellular Localization of Divalent Metal Transporter 1 Isoforms - Tabuchi, Tanaka, Nishida-Kitayama, Ohno, Kishi - Mol Biol Cell., 2002
5-[ 6 ]
Crypt epithelial cells and iron absorption
7-[ 8 ]
Intracellular signals of iron status and transferrin cycle
*
Helicobacter pylori perturbs iron trafficking in the epithelium to grow on the cell surface. - Tan, Noto, Romero-Gallo, Peek Jr, Amieva - PLoS Pathog., 2011

  • Without HP interference (1)

  • After HP colonization (1)

  • Without HP interference (2)

  • After HP colonization (2)

  • Without HP interference (3)

  • After HP colonization (3)

V. Direct Oncogenic Activity

1-2
Oncogenic mechanisms of the Helicobacter Pylori CagA protein - Hatakeyama - Nat Rev Cancer, 2004
3-4
Mechanisms of disease: Helicobacter pylori virulence factors - Yamaoka - Nat. Rev. Gastroenterol. Hepatol., 2010

VI. Effects on GI hormonal secretion and vitamin absorption

1
Helicobacter pylori infection and circulating ghrelin levels: a systematic review - Nweneka, Prentice - BMC Gastroenterology, 2011
2
Ghrelin and Helicobacter pylori infection - Osawa - World J Gastroenterol, 2008
3
Impaired Production of Gastric Ghrelin in Chronic Gastritis Associated with Helicobacter pylori - Osawa, Nakazato, Date, Kita, Ohnishi, Ueno, Shiiya, Satoh, Ishino, Sugano - J Clin Endocrinol Metab., 2005
*
Micronutrients (Other than iron) and Helicobacter pylori Infection: A Systematic Review - Lahner, Persechino, Annibale - Helicobacter, 2012

Attachments
fileuserdatecontrols
8112_HP-NAP_strutt.pngedo.manca2012-03-28
Adesine_1_3_HP.pngedo.manca2012-03-28
CagA_injection.pngedo.manca2012-03-28
CagA_oncogenic_mechanism.jpgedo.manca2012-03-29
CagA_pathway.pngedo.manca2012-03-28
Cag_A_3_3.jpgedo.manca2012-03-28
Chronic_inflamm.pngedo.manca2012-03-29
Ferro_tf.pngedo.manca2012-03-29
Ghrelina_leptina_JPG.jpgedo.manca2012-03-29
HP-NAP_Fe.pngedo.manca2012-03-28
HP-NAP_calcio_MAPk.pngedo.manca2012-03-28
HP-NAP_effetti.pngedo.manca2012-03-29
HP-NAP_infiammaz.pngedo.manca2012-03-29
HP-NAP_meccanismo.pngedo.manca2012-03-28
HP_ROS_1.jpgedo.manca2012-03-29
HP_e_tf_stomaco.pngedo.manca2012-03-29
HP_gener.pngedo.manca2012-03-28
HP_giunzioni_cell.pngedo.manca2012-03-28
HP_injection_cagA_e_PAI_EPIYA.jpgedo.manca2012-03-28
HP_nap_th1_th2_ultimo_1.pngedo.manca2012-03-29
Infiammaz_HP_wikipedia.pngedo.manca2012-03-28
Inserzione_oncogenic_CagA.jpgedo.manca2012-03-29
Pathogenesis_20of_20Helicobacter_20pylori_20Infection.jpgedo.manca2012-03-28
Stomaco_IF_grelin_inibiz.jpgedo.manca2012-03-29
Switch_HP-NAP.pngedo.manca2012-03-29
Th1_Th2.jpgedo.manca2012-03-29
Ureasi_HP_wiki.pngedo.manca2012-03-28
VacA_pathway.pngedo.manca2012-03-28
Vac_A_2.pngedo.manca2012-03-28
Vac_A_2_3.jpgedo.manca2012-03-28
cagA_cancer_2.jpgedo.manca2012-03-29
danno_mucosale_Lf_Tf.pngedo.manca2012-03-29
ferro_transf_intest.bmpedo.manca2012-03-29
ferro_transf_intest_HP.jpgedo.manca2012-03-29
istologic_HP.jpgedo.manca2012-03-28
oikA_HP.jpgedo.manca2012-03-29
regolazione_negativa_Th1_da_HP.pngedo.manca2012-03-29
tfR_schema.gifedo.manca2012-03-29
th1_th2_allergia_ultimo_2.pngedo.manca2012-03-29
transf_cicl.pngedo.manca2012-03-29
transferrina_ciclo.jpgedo.manca2012-03-29
transferrina_ciclo_HP_nature.jpgedo.manca2012-03-29
urease_Ni2_ph.pngedo.manca2012-03-28
virulence_factors_HP.pngedo.manca2012-03-28
Rules
Pathways
Apoptosis, Bacterial infection and cardiovascular disease, Competition for Iron, Cubilin and Megalin, Cytokines, Enzymes, Erythrocytes - iron homeostasis, Ferritin synthesis and degradation, Folic Acid, BH4 and Neopterin, Gastrin, Gastrointestinal Hormones, Ghrelin, Heme Proteins, Heme Synthesis , Hemopexin, Hepatocytes - iron homeostasis, Hepcidin, Homocysteine, Hypoxia Induced Genes, Inflammation, Interferon gamma (IFN-gamma), Interferons, Interleukin 1, Interleukin 10, Interleukin 12, Interleukin 18, Interleukin 6, Interleukins, Iron Metabolism, Iron Storage, Iron Sulfur Proteins, Iron Supply, Iron Therapy, Iron containing Proteins, Iron input, Iron input and output, Iron output, Lactoferrin , Leptin, Leukotrienes Synthesis, Membrane Receptors, Membrane Transport, Metalloproteinases, Methionine, Microvesicles as Signal Mediators, Minerals, Miscellaneous dietary supplements, Mitochondrial iron metabolism, NAD and NADP , NADH/NAD, NADPH/NADP, NFkB, Nitric Oxide , Nitric Oxide and Oral Diseases, Nitric oxide as a bioregulator of apoptosis, Oncogene, ROS (Reactive Oxygen Species), Respiration, Respiratory Chain, Siderophores, Signaling Pathway, Signaling Pathways, Thrombotic events, Thyroid Hormones , Transferrin, Transferrin Receptors, Transferrin and transferrin receptors, VITAMIN C, Vitamin A, Vitamin B1 (Thiamine), Vitamin B12, Vitamin B2, Vitamin B3 (Niacin/Nicotinic Acid), Vitamin B5, Vitamin B6, Vitamin C, Vitamin D, Vitamin D Deficiency, Vitamin D Resistance, Vitamin D as a Drug, Vitamin D efflux, Vitamin E, Vitamin K as cofactor, Vitamin K dependent Carboxylation, Vitamins
Reports
MeSH
Blood, Blood Coagulation, Mitochondria, Heart, Iron, Dietary, Iron Metabolism Disorders, Vitamin D, Diabetes Mellitus, Type 2, Thyroid Gland, Haptoglobins, Stomatitis, Blood Cells, Macrophages, Iron, Myocardial Infarction, Antioxidants, Thrombosis, Cadherins, Nitric Oxide, Hypothyroidism, Hypoxia-Inducible Factor 1, Cell Hypoxia, Apoptosis, Carcinoma, Proton Pumps, Homocysteine, Platelet Aggregation Inhibitors, Inflammatory Bowel Diseases, Cell Adhesion Molecules, Disease, Cardiomyopathies, Heart, Ascorbic Acid, Ascorbic Acid Deficiency, Signs and Symptoms, Headache, Panic, Ferritins, Free Radicals, Mitochondria, Vitamin D Response Element, Cyclic GMP, Purpura, Platelet Activation, Platelet Aggregation, Glaucoma, Cyclooxygenase 2, Blood Circulation, Asthma, Eye Diseases, Sodium, Membrane Transport Proteins, Lymphocytes, B-Lymphocyte Subsets, Intestinal Secretions, Cyclic AMP, Cyclic AMP Receptor Protein, Vitamin D Deficiency, Hypertension, Blood-Brain Barrier, Erythrocytes, Molecular Chaperones, Chaperonins, Hormones, Nitric Oxide Synthase, Glutathione, Anemia, Inflammation, Inflammation Mediators, Folic Acid, Cell Differentiation, Helicobacter Infections, Helicobacter pylori, Cytokines, Interferon Inducers, Intestinal Absorption, T-Lymphocyte Subsets, Signal Transduction, Dyspepsia, Venous Thrombosis, Cardiovascular Diseases, Cell Cycle Proteins, Cell Cycle, Mitochondrial Diseases, Lysosomes, Vitamin K 1, Periodontitis, Vitamin K Deficiency, Metalloproteases, Sleep Disorders, Endocarditis, Atherosclerosis, Mucins, Vitamin B 12, Vitamin B 12 Deficiency, Eosinophilia, Oxygen Compounds, Glutathione Reductase, Mouth, Nonheme Iron Proteins, Oxygen, Vascular Diseases, Leptin, Prothrombin, Restless Legs Syndrome, ATP-Binding Cassette Transporters, Ischemia, Sepsis, Extracellular Matrix, Food Habits, Tongue Diseases, Blood Coagulation Factors, Blood Coagulation Factor Inhibitors, Evolution, Erythropoietin, Immune System, Aspirin, Causality, Hemopexin, Embolism and Thrombosis, Gastrointestinal Hormones, Gastrins, Gastrin-Releasing Peptide, Gastrin-Secreting Cells, Bacteria, Disinfectants, Food, Granulocytes, Eosinophils, Oxygen Consumption, Infection, Cyclooxygenase 1, Interleukin-1, Cytoskeletal Proteins, Basal Metabolism, Vitamin D-Binding Protein, Gastrointestinal Diseases, Endosomes, Gap Junctions, C-Reactive Protein, Metabolism, Gene Expression, Heart Diseases, Irritable Bowel Syndrome, Gastrointestinal Hemorrhage, Caffeine, Vitamin B Complex, Peptic Ulcer Perforation, Thromboembolism, Protein C, Vasculitis, Drug Compounding, Benzodiazepines, Myocardial Ischemia, Molecular Mimicry
Attachments
fileuserdate
8112_HP-NAP_strutt.pngedo.manca28/03/2012
Adesine_1_3_HP.pngedo.manca28/03/2012
CagA_injection.pngedo.manca28/03/2012
CagA_oncogenic_mechanism.jpgedo.manca29/03/2012
CagA_pathway.pngedo.manca28/03/2012
Cag_A_3_3.jpgedo.manca28/03/2012
Chronic_inflamm.pngedo.manca29/03/2012
Ferro_tf.pngedo.manca29/03/2012
Ghrelina_leptina_JPG.jpgedo.manca29/03/2012
HP-NAP_Fe.pngedo.manca28/03/2012
HP-NAP_calcio_MAPk.pngedo.manca28/03/2012
HP-NAP_effetti.pngedo.manca29/03/2012
HP-NAP_infiammaz.pngedo.manca29/03/2012
HP-NAP_meccanismo.pngedo.manca28/03/2012
HP_ROS_1.jpgedo.manca29/03/2012
HP_e_tf_stomaco.pngedo.manca29/03/2012
HP_gener.pngedo.manca28/03/2012
HP_giunzioni_cell.pngedo.manca28/03/2012
HP_injection_cagA_e_PAI_EPIYA.jpgedo.manca28/03/2012
HP_nap_th1_th2_ultimo_1.pngedo.manca29/03/2012
Infiammaz_HP_wikipedia.pngedo.manca28/03/2012
Inserzione_oncogenic_CagA.jpgedo.manca29/03/2012
Pathogenesis_20of_20Helicobacter_20pylori_20Infection.jpgedo.manca28/03/2012
Stomaco_IF_grelin_inibiz.jpgedo.manca29/03/2012
Switch_HP-NAP.pngedo.manca29/03/2012
Th1_Th2.jpgedo.manca29/03/2012
Ureasi_HP_wiki.pngedo.manca28/03/2012
VacA_pathway.pngedo.manca28/03/2012
Vac_A_2.pngedo.manca28/03/2012
Vac_A_2_3.jpgedo.manca28/03/2012
cagA_cancer_2.jpgedo.manca29/03/2012
danno_mucosale_Lf_Tf.pngedo.manca29/03/2012
ferro_transf_intest.bmpedo.manca29/03/2012
ferro_transf_intest_HP.jpgedo.manca29/03/2012
istologic_HP.jpgedo.manca28/03/2012
oikA_HP.jpgedo.manca29/03/2012
regolazione_negativa_Th1_da_HP.pngedo.manca29/03/2012
tfR_schema.gifedo.manca29/03/2012
th1_th2_allergia_ultimo_2.pngedo.manca29/03/2012
transf_cicl.pngedo.manca29/03/2012
transferrina_ciclo.jpgedo.manca29/03/2012
transferrina_ciclo_HP_nature.jpgedo.manca29/03/2012
urease_Ni2_ph.pngedo.manca28/03/2012
virulence_factors_HP.pngedo.manca28/03/2012
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