Gastrin
Gastrointestinal Hormones

Author: Gianpiero Pescarmona
Date: 24/10/2010

Description

DEFINITION

Gastrin is a hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and stimulates gastric motility. It is released by G cells in the stomach, duodenum, and the pancreas.

Synonims: Neuromedin-C

Figura:!

THE GENE

DatabaseLink
WikigenesGASTGRPSST
GeneCards"URL":
Your Favorite Gene Sigma"URL":

CHEMICAL STRUCTURE AND IMAGES

When relevant for the function

  • Primary structure
  • Secondary structure
  • Tertiary structure
  • Quaternary structure


Protein Aminoacids Percentage
The Protein Aminoacids Percentage gives useful information on the local environment and the metabolic status of the cell (starvation, lack of essential AA, hypoxia)

Protein Aminoacids Percentage (Width 700 px)

SOMATOSTATIN HAS NO HISTIDINE (depleted by former histamine synthesis?)
Low Tyrosine and Proline (low NADPH because of 1) high DNA synthesis 2) low glucose supply)

SYNTHESIS AND TURNOVER

mRNA synthesis
protein synthesis

post-translational modifications
degradation

CELLULAR FUNCTIONS

Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.

cellular localization,
biological function

  • Enzymes
DatabaseLink
BRENDA - The Comprehensive Enzyme Information System"URL":
KEGG Pathways"URL":
Human Metabolome Database"URL":
  • Cell signaling and Ligand transport
  • Structural proteins

REGULATION

The vagus regulates histamine mobilization from rat stomach ECL cells by controlling their sensitivity to gastrin. 2005

Vagal excitation by hypoglycaemia (insulin) or pylorus ligation did not mobilize either gastrin or histamine. The histamine response to food was almost abolished by gastrin receptor blockade, and it was halved on the denervated side after unilateral subdiaphragmatic vagotomy.

GRP?

A HIF-1alpha-related gene involved in cell protection from hypoxia by suppression of mitochondrial function. 2008

DIAGNOSTIC USE

Attachments
fileuserdate
GAST-ET-AL-ch1.gifgp24/10/2010
GAST-ET-AL-ch2.gifgp24/10/2010
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