Heme-oxygenase (HO) is the first step of Heme degradation
Different Isoforms of Heme-oxygenase are active in different cells (HMOX-1, HMOX-2)
HO-1 is inducible by the same factors that induce COX-2 and iNOS
Heme Oxygenase-1 Gene Promoter Polymorphism is Associated with Risk of Gastric Adenocarcinoma and Lymphovascular Tumor Invasion.
Central CO-heme oxygenase pathway raises body temperature by a prostaglandin-independent way.
Effects of nitrogen monoxide and carbon monoxide on molecular and cellular iron metabolism 2003
Involvement of the Heme Oxygenase–Carbon Monoxide Pathway in Keratinocyte Proliferation
Biliverdin and more
Albumin: a multi-purpose carrier
Choleretic Effect of licorice
Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration, 2016
Compared to their normobilirubinemic siblings, aged hyperbilirubinemic Gunn rats showed significantly smaller amounts of visceral fat, better glucose tolerance, and decreased serum levels of proinflammatory cytokines TNFα, IL-1β, and IL-18. Simultaneously, livers from Gunn rats showed decreased expression of senescence markers and cell cycle inhibitors p21 and p16.
Is associated with Anemia, Diabetes, Osteoporosis, and (Aromatase deficiency?)