Coagulation Proteins Evolution

Author: Gianpiero Pescarmona
Date: 03/06/2010



  • Intrinsic pathway (blood)
    • Factor XII
    • Factor XI
    • Factor IX
  • Extrinsic pathway (tissue)
    • Factor VII (TFPI inhibits)
      • TFPI1
      • TFPI2

Fibrin Clot Formation Common Pathway

  • Factor X (ATIII inhibits)
  • Thrombin (Vit K) (ATIII inhibits)
    • ATIII
    • Fibrinogen
      • FIBA
      • FIBC
      • FIBG

Fibrin Clot Cross-linking

  • Factor XIII
    • Factor XIIIa
    • Factor XIIIb

Local Regulation

  • Factor V
  • Factor VIII


  • Thrombin


  • Protein C (Vit K)
    • Thrombomodulin
    • Protein S

Let's assume that the Glu/Gln ratio is a reliable marker of oxygen level in the environment when a protein appears for the first time.
According to this hypothesis due to evolutionary oxygen increase in the atmosphere the sequence of the proteins appearence should be:

Coagulation proteins ordered in ascending way according to Glu/Gln ratio

New research reveals oxygen's contributions to evolution 2006

As some coagulatory proteins are activated by post-translational modification Vitamin K -dependent, we checked also the behavior of proteins involved in bacterial synthesis of Vit. K or of human Co Q10, a structural and functional analog of Vit. K.

Proteins involved in Coenzyme Q/ Vit. K synthesis

COQ6 and COQ7 are human proteins involved in CoQ synthesis specific steps
MENB are proteins specific for bacterial Vitamin K synthesis

More details about O2 rise on a shorter time scale

O2 stepping increase
O2 stepping increase n.2
Oxygen rise and living organisms

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