Author: Gianpiero Pescarmona
PERIPHERAL DISTRIBUTION OF KYNURENINE METABOLITES AND ACTIVITY OF KYNURENINE PATHWAY ENZYMES IN RENAL FAILURE
Scheme of kynurenine pathway. TDO - tryptophan 2,3-dioxygenase, IDO - indoleamine 2,3-dioxygenase, KAT - kynurenine aminotransferase, KZ - kynureninase, HK - kynurenine 3-hydroxylase, HAO - 3-hydroxyanthranilate-3,4-dioxygenase. The total conentration of TRP metabolites and activity of kynurenic pathway enzymes was prsented (bracketedes).