Supplementation of coenzyme Q10 and alpha-tocopherol lowers glycated hemoglobin level and lipid peroxidation in pancreas of diabetic rats. 2008
Coenzima Q10 allevia sintomi miopatici nei pazienti trattati con statine
Il trattamento con coenzima Q10 allevia i sintomi di miopatia nei pazienti trattati con statine. Tale trattamento diminuisce sia la biosintesi del colesterolo che quella del coenzima Q10, ed il risultante deficit di tale coenzima può contribuire allo sviluppo di miopatie e sintomi muscolari descritti nei pazienti trattati con statine. L'integrazione del coenzima in questione diminuisce il dolore muscolare del 40 percento e migliora l'interferenza del dolore con le attività quotidiane del 38 percento. Ciò suggerisce che il coenzima Q10 può essere di beneficio nei pazienti sotto statine migliorando i sintomi miopatici ed il benessere e la funzionalità individuale nelle attività quotidiane. (Am J Cardiol 2007; 99: 1409-12)
Chin J Physiol. 2007 Oct 31;50(5):217-24.Links
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Chin J Physiol. 2007 Dec 31;50(6):330.
Effects of coenzyme Q10 on the heart ultrastructure and nitric oxide synthase during hyperthyroidism.
Oztay F, Ergin B, Ustunova S, Balci H, Kapucu A, Caner M, Demirci C.
Department of Biology, Faculty of Science, Istanbul University, Vezneciler. fusunoztay@yahoo.com
Coenzyme Q10 is an important component of mitochondrial electron transport chain and antioxidant. Hyperthyroidism manifests hyperdynamic circulation with increased cardiac output, increased heart rate and decreased peripheral resistance. The heart is also under the oxidative stress in the hyperthyroidism. The aim of this study was to examine both how the coenzyme Q10 can affect heart ultrastructure in the hyperthyroidism and how the relationship between nitric oxide synthase (NOS) and heart damage and coenzyme Q10. Swiss Black C57 mice received 5 mg/kg L-thyroxine. Coenzyme Q10 (1.5 mg/kg) and L-thyroxine together was given to second group mice. Coenzyme Q10 and serum physiologic were applied to another two groups, respectively. All treatments were performed daily for 15 days by gavage. Free triiodothyronine and thyroxine were increased in two groups given L-thyroxine; thyroid-stimulating hormone level did not change. Hyperthyroid heart showed an increased endothelial NOS (eNOS) and inducible NOS (iNOS) immunoreactivity in the tissue. Coenzyme Q10 administration decreased these NOS immunoreactivities in the hyperthyroid animals. Cardiomyocytes of the hyperthyroid animals was characterized by abnormal shape and invaginated nuclei, and degenerative giant mitochondria. Desmosome plaques reduced in density. In hyperthyroid mice given coenzyme Q10, the structural disorganization and mitochondrial damage regressed. However, hearts of healthy mice given coenzyme Q10 displayed normal ultrastructure, except for increased mitochondria and some of them were partially damaged. Coenzyme Q10 increased the glycogen in the cardiomyocytes. In conclusion, coenzyme Q10 administration can prevent the ultrastructural disorganization and decrease the iNOS and eNOS increment in the hyperthyroid heart.
CoQ Tissues distribution according to drug preparation
Drugs information
CoQ, Riboflavin, Niacin
In association with Tamoxifen
Papers Niacin Coenzyme Q
Vitamin D3 hydroxylation
The influence of Coenzyme Q10 on total serum calcium concentration in two patients with Kearns-Sayre Syndrome and hypoparathyroidism. 1996
Two patients with Kearns-Sayre Syndrome and hypoparathyroidism were treated with alfacalcidol (1a-OH D3) and total serum calcium concentration remained within normal range for a long period. After two months of combined therapy with Coenzyme Q10 (CoQ10), hypercalcemia was noticed and as a result, 1a-OHD3 was gradually discontinued. Normal total serum calcium concentration was obtained with CoQ10 monotherapy while the replacement of CoQ10 with placebo led to hypocalcemia. The mechanism of action of CoQ10 is difficult to explain. Since the parathormone level remained unchanged during CoQ10 or placebo therapy, we speculate that the capacity of producing an active form of vitamin D in mitochondria of proximal tubules was restored by CoQ10 therapy.
Coenzyme Q10 and adriamycin toxicity in mice. 1980
Res Commun Chem Pathol Pharmacol (1980) Show Abstract »
At higher i.v. adriamycin dose levels, CoQ10 pretreatment significantly enhanced acute toxicity.
[Chronic cardiotoxicity of anthracycline derivatives and possible prevention by coenzyme Q10]. 1984
Gan No Rinsho (1984) Show Abstract »
We studied the cardiotoxicity caused by ADR in New Zealand white rabbits and its protection by the medication of CoQ10.